1 experimentally studied protein
2 sequences in Swiss-Prot
2,702 unique sequences in UniRef100
Threonine aspartases from metazoans and fungi
Unique hexameric structure (concentration dependent)
| Fam ? Class - Clan - Family | Alt ? Alternative historical name / classification | AN ? UniProt accession number | Name ? UniProt entry name, only given here for Swiss-Prot entries | EC | Organism | Cell-Loc | AAs | Structure | PDB | Km i for Asn [mM] | Vmax i for Asn [μmol/min/mg] | Kcat i for Asn [s-1] | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2-3-9 | - | Q9H6P5 | TASP1_HUMAN | 3.4.25.- | Homo sapiens | i Overexpressed in primary human cancers. | 420 | Hetero tetramer / homo dimer / hexamer i Concentration dependent. | 6VIN PDBs | - | - | - |
| Fam ? Class - Clan - Family | Alt ? Alternative historical name / classification | AN ? UniProt accession number | Name ? UniProt entry name, only given here for Swiss-Prot entries | EC | Organism | Cell-Loc | AAs | Structure | PDB | Km i for Asn [mM] | Vmax i for Asn [μmol/min/mg] | Kcat i for Asn [s-1] | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2-3-9 | - | Q9H6P5 | TASP1_HUMAN | 3.4.25.- | Homo sapiens | i Overexpressed in primary human cancers. | 420 | Hetero tetramer / homo dimer / hexamer i Concentration dependent. | 6VIN PDBs | - | - | - | |
| 2-3-9 | - | Q8R1G1 | TASP1_MOUSE | 3.4.25.- | Mus musculus | - | 420 | - | - | - | - | - |
Clan 3 consists of three families, which are all eukaryotic threonine aspartases, many of these contain extra terminal amino acid residues compared to sequences in other clans.
Family 9 are threonine aspartases from metazoans and fungi, like the Homo sapiens enzyme (Q9H6P5), which can present as a tetramer or a hexamer depending on concentration. Taspase 1 is overexpressed in primary human cancer cells.
1Varadi, M et al. AlphaFold Protein Structure Database in 2024: providing structure coverage for over 214 million protein sequences. Nucleic Acids Research (2024). Licensed under CC BY 4.0.
2Suzek, B.E. et al. UniRef: comprehensive and non-redundant UniProt reference clusters. Bioinformatics (2007). Licensed under CC BY 4.0. Added classification code to sequence headers.
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