Class 2 Family 10

Family 10 Overview

5 experimentally studied proteins

5 sequences in Swiss-Prot

1,570 unique sequences in UniRef100

Archaeal and bacterial l‑asparaginases

Clan 4: Family 10, Family 11, Family 12

Reference Monomer¹

Reference Structure

Family 10 Motifs
(Q5JHT1)

motifs2-10

Experimentally Studied Proteins

	Fam ? Class - Clan - Family	Alt ? Alternative historical name / classification	AN ? UniProt accession number	Name ? UniProt entry name, only given here for Swiss-Prot entries	EC	Organism	Cell-Loc	AAs	Structure	PDB	K_m i for Asn [mM]	V_max i for Asn [μmol/min/mg]	K_cat i for Asn [s^-1]
	2-4-10	-	A0A0N7IWY2		3.5.1.1	Aquabacterium sp.		306	-	-	33.7	-	0.0087
	2-4-10	-	Q6L1Z2		3.5.1.1	Picrophilus torridus	-	297	-	-	11.69	-	0.056
	2-4-10	-	A3MUS8	ASPGP_PYRCJ	3.5.1.1	Pyrobaculum calidifontis	-	299	Dimer i Determined from gel filtration	-	4.5	355	374.0
	2-4-10	-	Q9V262	ASPGP_PYRAB	3.5.1.1	Pyrococcus abyssi	-	305	-	-	2.051	-	-
	2-4-10	-	Q5JHT1	ASPGP_THEKO	3.5.1.1	Thermococcus kodakarensis	-	306	Dimer i Determined from gel filtration	-	3.1	833	-

Swiss-Prot Sequences

	Fam ? Class - Clan - Family	Alt ? Alternative historical name / classification	AN ? UniProt accession number	Name ? UniProt entry name, only given here for Swiss-Prot entries	EC	Organism	Cell-Loc	AAs	Structure	PDB	K_m i for Asn [mM]	V_max i for Asn [μmol/min/mg]	K_cat i for Asn [s^-1]
	2-4-10	-	A3MUS8	ASPGP_PYRCJ	3.5.1.1	Pyrobaculum calidifontis	-	299	Dimer i Determined from gel filtration	-	4.5	355	374.0
	2-4-10	-	Q9V262	ASPGP_PYRAB	3.5.1.1	Pyrococcus abyssi	-	305	-	-	2.051	-	-
	2-4-10	-	Q8U4E6	ASPGP_PYRFU	3.5.1.1	Pyrococcus furiosus	-	306	-	-	-	-	-
	2-4-10	-	O57971	ASPGP_PYRHO	3.5.1.1	Pyrococcus horikoshii	-	305	-	-	-	-	-
	2-4-10	-	Q5JHT1	ASPGP_THEKO	3.5.1.1	Thermococcus kodakarensis	-	306	Dimer i Determined from gel filtration	-	3.1	833	-

UniRef100 Sequences²

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Representative Sequence Alignment

Motifs Image

Additional Information

Clan 4 enzymes are isoaspartyl peptidases and/or l‑asparaginases.

Family 10 and Family 11 both contain sequences from bacteria and archaea.

¹Varadi, M et al. AlphaFold Protein Structure Database in 2024: providing structure coverage for over 214 million protein sequences. Nucleic Acids Research (2024). Licensed under CC BY 4.0.

²Suzek, B.E. et al. UniRef: comprehensive and non-redundant UniProt reference clusters. Bioinformatics (2007). Licensed under CC BY 4.0. Added classification code to sequence headers.