Class 3 Family 1

Family 1 Overview

2 experimentally studied proteins

0 sequences in Swiss-Prot

3,284 unique sequences in UniRef100

Bacterial l‑asparaginases

l‑Asparaginase activity with minimal l‑glutaminase activity

Clan 1: Family 1

Reference Monomer¹

Reference Structure

Family 1 Motifs
(A0A0C5GVW3)

Experimentally Studied Proteins

	Fam ? Class - Clan - Family	Alt ? Alternative historical name / classification	AN ? UniProt accession number	Name ? UniProt entry name, only given here for Swiss-Prot entries	EC	Organism	Cell-Loc	AAs	Structure	PDB	K_m i for Asn [mM]	V_max i for Asn [μmol/min/mg]	K_cat i for Asn [s^-1]
	3-1-1	-	A0A0C5GVW3		3.5.1.1	Paenibacillus barengoltzii	-	336	Monomer i Determined by gel filtration.	-	3.6	162.2	-
	3-1-1	-	A0A068N0Z8		3.5.1.1	Synechocystis sp.	-	317	-	-	29	25.7	-

Swiss-Prot Sequences

UniRef100 Sequences²

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Representative Sequence Alignment

Additional Information

Clan 1 and Family 1 hold the characterized Synechococcus elongatus l‑asparaginase (A0A068N0Z8) (UniProt entry for an identical sequence of Synechocystis sp.) and the Paenibacillus barengoltzii l‑asparaginase (A0A0C5GVW3). The latter could have a native monomeric form, which is rare for l‑asparaginases.

¹Varadi, M et al. AlphaFold Protein Structure Database in 2024: providing structure coverage for over 214 million protein sequences. Nucleic Acids Research (2024). Licensed under CC BY 4.0.

²Suzek, B.E. et al. UniRef: comprehensive and non-redundant UniProt reference clusters. Bioinformatics (2007). Licensed under CC BY 4.0. Added classification code to sequence headers.