0 experimentally studied proteins
0 sequences in Swiss-Prot
308 unique sequences in UniRef100
Putative l‑asparaginases from bacteria and eukaryotes (algae, fungi, metazoans)
Diverse sequences with very poorly conserved motifs
Clan 3 is a small clan with only two families and no experimentally studied l‑asparaginase. Many, not all, l‑asparaginases in the clan show low sequence identity to any known l‑asparaginases (~20% or lower).
Family 8 is remarkably diverse phylogenetically and structurally. It contains sequences from bacteria and eukaryotes, including algae, fungi, and some metazoans. Many have the preserved catalytic motifs of Class 1 l‑asparaginases and show conservation of the l‑asparaginase domain (up to ~0.85 TM-score to l‑asparaginases with solved structures), but plenty are just fragments, lack the catalytic motifs or are part of a larger protein.
1Varadi, M et al. AlphaFold Protein Structure Database in 2024: providing structure coverage for over 214 million protein sequences. Nucleic Acids Research (2024). Licensed under CC BY 4.0.
2Suzek, B.E. et al. UniRef: comprehensive and non-redundant UniProt reference clusters. Bioinformatics (2007). Licensed under CC BY 4.0. Added classification code to sequence headers.
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