Class 1 Family 10

Family 10 Overview

1 experimentally studied protein

0 sequences in Swiss-Prot

989 unique sequences in UniRef100

Short-chain bacterial l‑asparaginases that lack the C-terminal stabilizing domain

Specific tetrametic structure

Clan 4: Family 10, Family 11, Family 12, Family 13

Reference Monomer¹

Reference Structure

Family 10 Motifs
(A0A2W4MD19)

Experimentally Studied Proteins

	Fam ? Class - Clan - Family	Alt ? Alternative historical name / classification	AN ? UniProt accession number	Name ? UniProt entry name, only given here for Swiss-Prot entries	EC	Organism	Cell-Loc	AAs	Structure	PDB	K_m i for Asn [mM]	V_max i for Asn [μmol/min/mg]	K_cat i for Asn [s^-1]
	1-4-10	-	Q2RMX1		3.5.1.1	Rhodospirillum rubrum	-	172	Homo tetramer i Specific tetrameric structure, as this family lacks the C-terminal stabilizing domain present in the other Class 1 families	8UOO PDBs	2.9 3.6 0.280 i Later results indicate a millimolar Km	-	57.1 58.2

Swiss-Prot Sequences

UniRef100 Sequences²

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Representative Sequence Alignment

Additional Information

Clan 4 is an interesting clan of bacterial and archaeal l‑asparaginases. Some sequences display characteristics of both "type I" and "type II" l‑asparaginases and some are structurally unique.

¹Varadi, M et al. AlphaFold Protein Structure Database in 2024: providing structure coverage for over 214 million protein sequences. Nucleic Acids Research (2024). Licensed under CC BY 4.0.

²Suzek, B.E. et al. UniRef: comprehensive and non-redundant UniProt reference clusters. Bioinformatics (2007). Licensed under CC BY 4.0. Added classification code to sequence headers.